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Solution structure of human BRG1 bromodomain

Analyse Solution structure of human BRG1 bromodomain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2H60
Type: protein
Length: 105 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable global transcription activator SNF2L4
EC: 3.6.1.-
UniProt: P51532
Pockets: 2 · best druggability 0.76

Structure

solution nmr · 1 distinct chain · 64% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable global transcription activator SNF2L4 (EC 3.6.1.-)	protein	105	64% helix, 0% strand	P51532

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	340	0.76	0.87	38	empty
2	76	0.39	0.78	16	empty

Compared structures

2H60 · Solution Structure of Human Brg1 Bromodomain · the same entry in another collection · chain A against A, TM-score 1.00
P51532 · AlphaFold monomer V2.0 prediction for transcription activator BRG1 (P51532) · a predicted model of the same protein · chain A against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51532
Elsewhere: RCSB PDB 2H60 · PDBe 2H60 · UniProt P51532

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