UniProt P51532
Transcription activator BRG1 (P51532)
Transcription activator BRG1 (UniProt P51532), EC 3.6.4.-: 21 experimental structures on GenesisL1, 9 ligands bound, 13 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P51532
- Protein
- Transcription activator BRG1
- EC
- 3.6.4.-
- Experimental structures
- 21
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 13 · 3 records with a druggable one
Structures
21 records of P51532 in the MolNFT archive: 21 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2GRC | 1.5 A structure of bromodomain from human BRG1 protein, a central ATPase of SWI/SNF remodeling… | x-ray diffraction | A | — | — |
| 2GRC | 1.5 a structure of bromodomain from human BRG1 protein, a central ATPase of SWI/SNF remodeling… | x-ray diffraction | A | — | — |
| 2H60 | Solution Structure of Human Brg1 Bromodomain | solution nmr | A | — | — |
| 2H60 | Solution structure of human BRG1 bromodomain | solution nmr | A | — | — |
| 3UVD | Crystal Structure of the bromodomain of human Transcription activator BRG1 (SMARCA4) in complex… | x-ray diffraction | A | — | — |
| 3UVD | Crystal structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex… | x-ray diffraction | A | — | — |
| 5DKD | Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3 chemical probe | x-ray diffraction | A, B | ZN, 5BW | — |
| 5DKD | Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with pfi-3 chemical probe | x-ray diffraction | A, B | — | — |
| 5EA1 | Crystal Structure of SMARCA4 bromodomain in complex with MPD | x-ray diffraction | A, B, C | — | — |
| 5EA1 | Crystal structure of SMARCA4 bromodomain in complex with mpd | x-ray diffraction | A, B, C | — | — |
| 6HR2 | Crystal structure of protac 2 in complex with the bromodomain of human SMARCA4 and… | x-ray diffraction | A, E | FWZ | — |
| 6LTH | Structure of human BAF Base module | electron microscopy | I | — | 6 (best 0.83) |
| 6LTH | Structure of human baf base module | electron microscopy | I | — | — |
| 6LTJ | Structure of nucleosome-bound human BAF complex | electron microscopy | I | — | 6 (best 0.84) |
| 6LTJ | Structure of nucleosome-bound human baf complex | electron microscopy | I | — | — |
| 6ZS2 | Crystal structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex… | x-ray diffraction | A, B | FX5 | — |
| 7VDT | The motor-nucleosome module of human chromatin remodeling pbaf- nucleosome complex | electron microscopy | A | BEF, MG, ADP | — |
| 7VDV | The overall structure of human chromatin remodeling pbaf-nucleosome complex | electron microscopy | A | BEF, MG, ADP | — |
| 8EB1 | Chim2 - Intragenic antimicrobial peptide | solution nmr | A | — | — |
| 8G1Q | Co-crystal structure of Compound 1 in complex with the bromodomain of human SMARCA4 and… | x-ray diffraction | H | NA, YHB | 1 (best 0.72) |
| P51532 | AlphaFold monomer V2.0 prediction for transcription activator BRG1 (P51532) | — | — | — |
Ligands
- ADP · Adenosine-5'-diphosphate · in 2 records
- BEF · Beryllium trifluoride ion · in 2 records
- MG · Magnesium ion · in 2 records
- 5BW · (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one · in 1 record
- FWZ · (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide · in 1 record
- FX5 · 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl) phenol · in 1 record
- NA · Sodium ion · in 1 record
- YHB · N-(2-{4-[(6M)-3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl}pyridine-4-carbonyl)-3-methyl-L-valyl-(4R)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide · in 1 record
- ZN · Zinc ion · in 1 record
Elsewhere
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