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Tandem chromodomains of budding yeast CHD1

Analyse Tandem chromodomains of budding yeast CHD1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2H1E
Type: protein
Length: 329 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chromo domain protein 1
EC: 3.6.1.-
UniProt: P32657
Pockets: 1 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 44% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chromo domain protein 1 (EC 3.6.1.-)	protein	166	43% helix, 26% strand	P32657
B	Chromo domain protein 1 (EC 3.6.1.-)	protein	163	45% helix, 26% strand	P32657

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1097	0.72	0.76	79	empty

Interfaces

1 interface between chains.

A–B · 1187 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

2H1E · Tandem chromodomains of budding yeast CHD1 · the same entry in another collection · chain A against A, TM-score 1.00
P32657 · AlphaFold monomer V2.0 prediction for chromo domain-containing protein 1 (P32657) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32657
Elsewhere: RCSB PDB 2H1E · PDBe 2H1E · UniProt P32657

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