UniProt P32657
Chromo domain-containing protein 1 (P32657)
Chromo domain-containing protein 1 (UniProt P32657), EC 3.6.4.-: 21 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P32657
- Protein
- Chromo domain-containing protein 1
- EC
- 3.6.4.-
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 27 · 3 records with a druggable one
Structures
22 records of P32657 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2DY7 | Solution structure of the first chromodomain of yeast Chd1 | solution nmr | A | — | — |
| 2DY7 | Solution structure of the first chromodomain of yeast CHD1 | solution nmr | A | — | — |
| 2DY8 | Solution structure of the second chromodomain of yeast Chd1 | solution nmr | A | — | — |
| 2DY8 | Solution structure of the second chromodomain of yeast CHD1 | solution nmr | A | — | — |
| 2H1E | Tandem chromodomains of budding yeast CHD1 | x-ray diffraction | A, B | — | — |
| 2H1E | Tandem chromodomains of budding yeast CHD1 | x-ray diffraction | A, B | — | — |
| 2XB0 | DNA-binding domain from Saccharomyces cerevisiae chromatin- remodelling protein Chd1 | x-ray diffraction | X | — | — |
| 2XB0 | DNA-binding domain from saccharomyces cerevisiae chromatin- remodelling protein CHD1 | x-ray diffraction | X | — | — |
| 3MWY | Crystal structure of the chromodomain-ATPase portion of the yeast Chd1 chromatin remodeler | x-ray diffraction | W | — | — |
| 3MWY | Crystal structure of the chromodomain-ATPase portion of the yeast CHD1 chromatin remodeler | x-ray diffraction | W | — | — |
| 3TED | Crystal structure of the Chd1 DNA-binding domain in complex with a DNA duplex | x-ray diffraction | A | — | — |
| 3TED | Crystal structure of the CHD1 DNA-binding domain in complex with a DNA duplex | x-ray diffraction | A | — | — |
| 5J70 | The Chd1 DNA-binding domain in complex with 17mer DNA duplex | x-ray diffraction | A, B | — | — |
| 5J70 | The CHD1 DNA-binding domain in complex with 17MER DNA duplex | x-ray diffraction | A, B | — | — |
| 5O9G | Structure of nucleosome-CHD1 complex | electron microscopy | W | ADP, BEF | — |
| 6G0L | Structure of two molecules of the chromatin remodelling enzyme Chd1 bound to a nucleosome | electron microscopy | M, W | ADP, BEF | 12 (best 0.88) |
| 6G0L | Structure of two molecules of the chromatin remodelling enzyme CHD1 bound to a nucleosome | electron microscopy | M, W | ADP, BEF | — |
| 7NKX | RNA polymerase II-SPT4/5-nucleosome-CHD1 structure | electron microscopy | W | ADP, BEF | — |
| 7TN2 | Composite model of a CHD1-nucleosome complex in the nucleotide-free state derived from 2.3A and… | electron microscopy | W | — | — |
| 9GD1 | Structure of Chd1 bound to a hexasome-nucleosome complex with a dyad-to-dyad distance of 103 bp. | electron microscopy | W | ADP, BEF, MG | 7 (best 0.81) |
| 9GD2 | Structure of Chd1 bound to a dinucleosome with a dyad-to-dyad distance of 103 bp. | electron microscopy | S, T, W | ADP, BEF, MG | 8 (best 0.82) |
| P32657 | AlphaFold monomer V2.0 prediction for chromo domain-containing protein 1 (P32657) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5J70 chain A against the predicted model P32657: TM-score 0.96, RMSD 1.23 Å
- 5J70 chain A against the predicted model P32657: TM-score 0.96, RMSD 1.23 Å
- 7NKX chain W against the predicted model P32657: TM-score 0.95, RMSD 2.00 Å
- 6G0L chain W against the predicted model P32657: TM-score 0.95, RMSD 2.37 Å
- 6G0L chain W against the predicted model P32657: TM-score 0.95, RMSD 2.37 Å
- 2H1E chain A against the predicted model P32657: TM-score 0.95, RMSD 1.28 Å
- 2H1E chain A against the predicted model P32657: TM-score 0.95, RMSD 1.28 Å
- 2H1E chain B against the predicted model P32657: TM-score 0.95, RMSD 1.28 Å
- 2H1E chain B against the predicted model P32657: TM-score 0.95, RMSD 1.28 Å
- 6G0L chain M against the predicted model P32657: TM-score 0.95, RMSD 2.48 Å
Elsewhere
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