Research workbench
Human phosphatidylinositol-4-phosphate 5-kinase, type II, gamma
Analyse Human phosphatidylinositol-4-phosphate 5-kinase, type II, gamma in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2GK9
- Type
- protein
- Length
- 988 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma
- EC
- 2.7.1.68
- UniProt
- Q8TBX8
- Pockets
- 16 · best druggability 0.71
Structure
x-ray diffraction · 3 distinct chains · 36% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma (EC 2.7.1.68) | protein | 243 | 36% helix, 16% strand | Q8TBX8 |
| B, D | Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma (EC 2.7.1.68) | protein | 250 | 39% helix, 21% strand | Q8TBX8 |
| C | Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma (EC 2.7.1.68) | protein | 245 | 33% helix, 20% strand | Q8TBX8 |
Pockets
16 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 407 | 0.71 | 0.82 | 46 | empty |
| 2 | 492 | 0.68 | 0.79 | 59 | empty |
| 3 | 358 | 0.68 | 0.81 | 49 | empty |
| 4 | 360 | 0.64 | 0.79 | 40 | empty |
| 5 | 333 | 0.64 | 0.79 | 36 | empty |
Interfaces
5 interfaces between chains.
- B–C · 1098 Ų buried · 15 hydrogen bonds · protein-protein
- A–D · 1051 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 386 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 348 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 95 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2GK9 · Human Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma · the same entry in another collection · chain A against A, TM-score 1.00
- Q8TBX8 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 5-phosphate 4-kinase type-2… · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TBX8
- Elsewhere: RCSB PDB 2GK9 · PDBe 2GK9 · UniProt Q8TBX8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.