UniProt Q8TBX8

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Q8TBX8)

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (UniProt Q8TBX8), EC 2.7.1.149: 5 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 6 pockets. Binding sites, druggability and experiment against…

UniProt: Q8TBX8
Protein: Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
EC: 2.7.1.149
Experimental structures: 5
Predicted models: 1
Ligands: 2
Pockets: 6 · 2 records with a druggable one

Structures

6 records of Q8TBX8 in the MolNFT archive: 5 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
2GK9	Human Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma	x-ray diffraction	A, B, C, D	—	—
2GK9	Human phosphatidylinositol-4-phosphate 5-kinase, type II, gamma	x-ray diffraction	A, B, C, D	—	—
7QIE	Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric…	x-ray diffraction	A, B, C, D	DVF	—
7QIE	Crystal structure of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K2C) bound to an allosteric…	x-ray diffraction	A, B, C, D	DVF	—
8BQ4	Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an inhibitor	x-ray diffraction	A, B	QZR	4 (best 0.64)
Q8TBX8	AlphaFold monomer V2.0 prediction for phosphatidylinositol 5-phosphate 4-kinase type-2 gamma…	predicted	A	—	2 (best 0.75)

Ligands

DVF · 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-4-amine · in 2 records
QZR · 6-methyl-~{N}-(4-methylsulfonylphenyl)thieno[2,3-d]pyrimidin-4-amine · in 1 record

Experiment against prediction

8BQ4 chain A against the predicted model Q8TBX8: TM-score 0.99, RMSD 0.71 Å
8BQ4 chain B against the predicted model Q8TBX8: TM-score 0.99, RMSD 0.77 Å
7QIE chain B against the predicted model Q8TBX8: TM-score 0.98, RMSD 0.87 Å
7QIE chain B against the predicted model Q8TBX8: TM-score 0.98, RMSD 0.87 Å
2GK9 chain C against the predicted model Q8TBX8: TM-score 0.98, RMSD 0.82 Å
2GK9 chain C against the predicted model Q8TBX8: TM-score 0.98, RMSD 0.82 Å
2GK9 chain B against the predicted model Q8TBX8: TM-score 0.98, RMSD 0.86 Å
2GK9 chain B against the predicted model Q8TBX8: TM-score 0.98, RMSD 0.86 Å
2GK9 chain A against the predicted model Q8TBX8: TM-score 0.98, RMSD 0.86 Å
2GK9 chain A against the predicted model Q8TBX8: TM-score 0.98, RMSD 0.86 Å

Elsewhere

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