Research workbench
Double tudor domain complex structure
Analyse Double tudor domain complex structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2GFA
- Type
- protein
- Length
- 231 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Jumonji domain-containing protein 2A; Peptide
- UniProt
- O75164
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 3 distinct chains · 5% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Jumonji domain-containing protein 2A | protein | 107 | 6% helix, 56% strand | O75164 |
| B | Jumonji domain-containing protein 2A | protein | 110 | 5% helix, 54% strand | O75164 |
| C, D | Peptide | protein | 7 | 0% helix, 14% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 154 | 0.43 | 0.74 | 32 | empty |
| 2 | 95 | 0.38 | 0.76 | 21 | empty |
Interfaces
6 interfaces between chains.
- A–B · 560 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 544 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 532 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 77 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 36 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (methylation).
Compared structures
- 2GFA · double tudor domain complex structure · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75164
- Elsewhere: RCSB PDB 2GFA · PDBe 2GFA · UniProt O75164
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