Research workbench
Crystal structure of 15-hydroxyprostaglandin dehydrogenase TYPE1, complexed with NAD+
Analyse Crystal structure of 15-hydroxyprostaglandin dehydrogenase TYPE1, complexed… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2GDZ
- Type
- protein
- Length
- 266 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
- EC
- 1.1.1.141
- UniProt
- P15428
- Ligands
- NAD
- Pockets
- 1 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (EC 1.1.1.141) | protein | 266 | 52% helix, 17% strand | P15428 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 499 | 0.78 | 0.85 | 58 | NAD |
Compared structures
- 2GDZ · Crystal structure of 15-hydroxyprostaglandin dehydrogenase type1, complexed with NAD+ · the same entry in another collection · chain A against A, TM-score 1.00
- P15428 · AlphaFold monomer V2.0 prediction for 15-hydroxyprostaglandin dehydrogenase [NAD(+)]… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15428
- Elsewhere: RCSB PDB 2GDZ · PDBe 2GDZ · UniProt P15428
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