Crystal structure of siglec-7 in complex with methyl-9-(aminooxalyl- amino)-9-DEOXYNEU5AC (oxamido-NEU5AC)

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 40% strand (DSSP).

Ligands and binding sites

• NXD · methyl 5-acetamido-9-{[amino(oxo)acetyl]amino}-3,5,9-trideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosidonic acid · ligand · chains A
• CYS · Cysteine · ligand · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 1 covalent, 1 disulfide, 1 glycan (covalent ligand, disulfide, N-glycosylation).

Compared structures

• 2G5R · Crystal structure of Siglec-7 in complex with methyl-9-(aminooxalyl-amino)-9-deoxyNeu5Ac… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9Y286 · AlphaFold monomer V2.0 prediction for sialic acid-binding ig-like lectin 7 (Q9Y286) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9Y286
• Elsewhere: RCSB PDB 2G5R · PDBe 2G5R · UniProt Q9Y286