Research workbench
Crystal structure of human DNA polymerase gamma accessory subunit
Analyse Crystal structure of human DNA polymerase gamma accessory subunit in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2G4C
- Type
- protein
- Length
- 1,588 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA polymerase gamma subunit 2
- EC
- 2.7.7.7
- UniProt
- Q9UHN1
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | DNA polymerase gamma subunit 2 (EC 2.7.7.7) | protein | 397 | 36% helix, 22% strand | Q9UHN1 |
| C, D | DNA polymerase gamma subunit 2 (EC 2.7.7.7) | protein | 397 | 33% helix, 21% strand | Q9UHN1 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 737 | 0.84 | 0.87 | 54 | empty |
| 2 | 736 | 0.83 | 0.86 | 59 | empty |
| 3 | 1150 | 0.80 | 0.82 | 115 | empty |
| 4 | 935 | 0.75 | 0.78 | 112 | empty |
| 5 | 620 | 0.66 | 0.76 | 80 | empty |
Interfaces
4 interfaces between chains.
- A–C · 3003 Ų buried · 26 hydrogen bonds · protein-protein
- B–D · 2995 Ų buried · 26 hydrogen bonds · protein-protein
- B–C · 656 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 164 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2G4C · Crystal Structure of human DNA polymerase gamma accessory subunit · the same entry in another collection · chain D against D, TM-score 1.00
- Q9UHN1 · AlphaFold monomer V2.0 prediction for DNA polymerase subunit gamma-2, mitochondrial… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UHN1
- Elsewhere: RCSB PDB 2G4C · PDBe 2G4C · UniProt Q9UHN1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.