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Crystal structure of mthk rck domain in its ligand-free gating-ring form

Analyse Crystal structure of mthk rck domain in its ligand-free gating-ring form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2FY8
Type: protein
Length: 1,776 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calcium-gated potassium channel mthk
UniProt: O27564
Pockets: 14 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	Calcium-gated potassium channel mthk	protein	222	41% helix, 22% strand	O27564

Pockets

14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1161	0.73	0.77	142	empty
2	497	0.72	0.82	37	empty
3	1033	0.72	0.76	128	empty
4	475	0.71	0.81	36	empty
5	303	0.62	0.79	43	empty

Interfaces

12 interfaces between chains.

B–C · 3797 Å² buried · 60 hydrogen bonds · protein-protein
F–G · 3749 Å² buried · 46 hydrogen bonds · protein-protein
G–H · 813 Å² buried · 8 hydrogen bonds · protein-protein
C–D · 799 Å² buried · 16 hydrogen bonds · protein-protein
E–F · 798 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

2FY8 · Crystal structure of MthK rck domain in its ligand-free gating-ring form · the same entry in another collection · chain H against H, TM-score 1.00
O27564 · AlphaFold monomer V2.0 prediction for calcium-gated potassium channel mthk (O27564) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O27564
Elsewhere: RCSB PDB 2FY8 · PDBe 2FY8 · UniProt O27564

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