Research workbench
NMR solution structure of the yeast kinetochore SPC24/SPC25 globular domain
Analyse NMR solution structure of the yeast kinetochore SPC24/SPC25 globular domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FV4
- Type
- protein
- Length
- 147 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical 25.2 kda protein in AFG3-SEB2 intergenic region; Hypothetical 24.6 kda…
- UniProt
- P40014, Q04477
- Pockets
- 2 · best druggability 0.62
Structure
solution nmr · 2 distinct chains · 42% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical 25.2 kda protein in AFG3-SEB2 intergenic region | protein | 89 | 45% helix, 20% strand | P40014 |
| B | Hypothetical 24.6 kda protein in ILV2-ADE17 intergenic region | protein | 58 | 38% helix, 24% strand | Q04477 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.62 | 0.93 | 20 | empty |
| 2 | 201 | 0.55 | 0.78 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 1036 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2FV4 · NMR solution structure of the yeast kinetochore Spc24/Spc25 globular domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q04477 · AlphaFold monomer V2.0 prediction for kinetochore protein SPC24 (Q04477) · a predicted model of the same protein · chain B against A, TM-score 0.70
- P40014 · AlphaFold monomer V2.0 prediction for kinetochore protein SPC25 (P40014) · a predicted model of the same protein · chain A against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40014
- Every structure of UniProt Q04477
- Elsewhere: RCSB PDB 2FV4 · PDBe 2FV4 · UniProt P40014 · UniProt Q04477
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