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Solution structure of the UBCH5C/UB non-covalent complex

Analyse Solution structure of the UBCH5C/UB non-covalent complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2FUH
Type: protein
Length: 222 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin-conjugating enzyme E2 D3; Ubiquitin
EC: 6.3.2.19
UniProt: P61077, P62988
Pockets: 2 · best druggability 0.64

Structure

solution nmr · 2 distinct chains · 31% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin-conjugating enzyme E2 D3 (EC 6.3.2.19)	protein	146	36% helix, 14% strand	P61077
B	Ubiquitin	protein	76	21% helix, 24% strand	P62988

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	96	0.64	0.89	29	empty
2	191	0.58	0.81	31	empty

Interfaces

1 interface between chains.

A–B · 579 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

2FUH · Solution Structure of the UbcH5c/Ub Non-covalent Complex · the same entry in another collection · chain A against A, TM-score 1.00
P61077 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 D3 (P61077) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61077
Every structure of UniProt P62988
Elsewhere: RCSB PDB 2FUH · PDBe 2FUH · UniProt P61077 · UniProt P62988

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