UniProt P61077
Ubiquitin-conjugating enzyme E2 D3 (P61077)
Ubiquitin-conjugating enzyme E2 D3 (UniProt P61077), EC 2.3.2.23, 2.3.2.24: 29 experimental structures on GenesisL1, 2 ligands bound, 10 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P61077
- Protein
- Ubiquitin-conjugating enzyme E2 D3
- EC
- 2.3.2.23, 2.3.2.24, 2.3.2.27
- Experimental structures
- 29
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 10 · 4 records with a druggable one
Structures
29 records of P61077 in the MolNFT archive: 29 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1X23 | Crystal structure of ubch5c | x-ray diffraction | A, B, C, D | — | — |
| 1X23 | Crystal structure of UBCH5C | x-ray diffraction | A, B, C, D | — | — |
| 2FUH | Solution Structure of the UbcH5c/Ub Non-covalent Complex | solution nmr | A | — | — |
| 2FUH | Solution structure of the UBCH5C/UB non-covalent complex | solution nmr | A | — | — |
| 3L1Z | Crystal structure of the U-BOX domain of human E4B ubiquitin ligase in complex with UBCH5C E2… | x-ray diffraction | A | — | — |
| 3L1Z | Crystal structure of the U-box domain of human E4B ubiquitin ligase in complex with UBCH5C E2… | x-ray diffraction | A | — | — |
| 3RPG | Bmi1/Ring1b-UbcH5c complex structure | x-ray diffraction | A | — | — |
| 3RPG | BMI1/RING1B-UBCH5C complex structure | x-ray diffraction | A | — | — |
| 3UGB | UbcH5c~Ubiquitin Conjugate | x-ray diffraction | A | — | — |
| 3UGB | UBCH5C~UBIQUITIN conjugate | x-ray diffraction | A | — | — |
| 4BVU | Structure of Shigella effector OspG in complex with host UbcH5c- Ubiquitin conjugate | x-ray diffraction | B | — | — |
| 4BVU | Structure of shigella effector ospg in complex with host UBCH5C- ubiquitin conjugate | x-ray diffraction | B | — | — |
| 4R8P | Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core… | x-ray diffraction | L, N | — | — |
| 4R8P | Crystal structure of the RING1B/BMI1/UBCH5C PRC1 ubiquitylation module bound to the nucleosome core… | x-ray diffraction | L, N | — | — |
| 4S3O | PCGF5-RING1B-UbcH5c complex | x-ray diffraction | A, D | — | — |
| 4S3O | PCGF5-RING1B-UBCH5C complex | x-ray diffraction | A, D | — | — |
| 5EGG | Crystal structure of human ubiquitin-conjugating enzyme UBCH5C | x-ray diffraction | A | — | — |
| 5IFR | Structure of the stable UBE2D3-UbDha conjugate | x-ray diffraction | A | — | — |
| 5IFR | Structure of the stable UBE2D3-ubdha conjugate | x-ray diffraction | A | — | — |
| 6CP0 | SdcA in complex with the E2, UbcH5C | x-ray diffraction | B | — | 1 (best 0.58) |
| 6CP0 | Sdca in complex with the E2, UBCH5C | x-ray diffraction | B | — | — |
| 6T7F | RCR E3 ligase E2-Ubiquitin transthiolation intermediate | x-ray diffraction | B | LWZ | — |
| 6T7F | Rcr E3 ligase E2-ubiquitin transthiolation intermediate | x-ray diffraction | B | LWZ | — |
| 7JZV | Cryo-EM structure of the BRCA1-UBCH5C/BARD1 E3-E2 module bound to a nucleosome | electron microscopy | A | ZN | — |
| 7LYB | Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UBCH5C | electron microscopy | P | — | — |
| 8SN8 | Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub… | electron microscopy | L | — | 3 (best 0.77) |
| 8UQC | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization… | x-ray diffraction | A | ZN | 4 (best 0.55) |
| 8X7I | Cryo-EM structures of RNF168/UbcH5c-Ub in complex with H2AK13Ub nucleosomes determined by… | electron microscopy | K | — | 2 (best 0.78) |
| P61077 | AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 D3 (P61077) | — | — | — |
Ligands
Experiment against prediction
- 8UQC chain A against the predicted model P04908: TM-score 0.21, RMSD 0.93 Å
Elsewhere
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