Research workbench
Crystal structure of the glycine receptor-gephyrin complex
Analyse Crystal structure of the glycine receptor-gephyrin complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FTS
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gephyrin; Glycine receptor beta chain precursor
- UniProt
- Q03555, P20781
- Pockets
- 2 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gephyrin | protein | 419 | 20% helix, 33% strand | Q03555 |
| P | Glycine receptor beta chain precursor | protein | 13 | 23% helix, 0% strand | P20781 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 123 | 0.41 | 0.76 | 20 | empty |
| 2 | 120 | 0.39 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–P · 776 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 2FTS · Crystal structure of the glycine receptor-gephyrin complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q03555 · AlphaFold monomer V2.0 prediction for gephyrin (Q03555) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P20781 · AlphaFold monomer V2.0 prediction for glycine receptor subunit beta (P20781) · a predicted model of the same protein · chain P against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03555
- Every structure of UniProt P20781
- Elsewhere: RCSB PDB 2FTS · PDBe 2FTS · UniProt Q03555 · UniProt P20781
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