Research workbench

Dengue virus NS2B/NS3 protease

Analyse Dengue virus NS2B/NS3 protease in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2FOM
Type: protein
Length: 196 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polyprotein
EC: 3.4.21.91
UniProt: Q91H74
Ligands: CL
Pockets: 1 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polyprotein	protein	46	13% helix, 22% strand	Q91H74
B	Polyprotein (EC 3.4.21.91)	protein	150	5% helix, 50% strand	Q91H74

Ligands and binding sites

CL · Chloride ion · ion · chains B
GOL · Glycerol · additive · 2 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	139	0.47	0.78	23	GOL

Interfaces

1 interface between chains.

A–B · 1704 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

2FOM · Dengue Virus NS2B/NS3 Protease · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q91H74
Elsewhere: RCSB PDB 2FOM · PDBe 2FOM · UniProt Q91H74

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