UniProt Q91H74
Genome polyprotein (Q91H74)
Genome polyprotein (UniProt Q91H74): 37 experimental structures on GenesisL1, 16 ligands bound, 73 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q91H74
- Protein
- Genome polyprotein
- Experimental structures
- 37
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 73 · 10 records with a druggable one
Structures
37 records of Q91H74 in the MolNFT archive: 37 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2BHR | Dengue virus RNA helicase | x-ray diffraction | A, B | — | — |
| 2BHR | Dengue virus RNA helicase | x-ray diffraction | A, B | — | — |
| 2BMF | Dengue virus RNA helicase at 2.4A | x-ray diffraction | A, B | — | — |
| 2BMF | Dengue virus RNA helicase at 2.4A | x-ray diffraction | A, B | — | — |
| 2FOM | Dengue Virus NS2B/NS3 Protease | x-ray diffraction | A, B | — | — |
| 2FOM | Dengue virus NS2B/NS3 protease | x-ray diffraction | A, B | — | — |
| 4M9F | Dengue virus NS2B-NS3 protease A125C variant at pH 8.5 | x-ray diffraction | A | — | — |
| 4M9F | Dengue virus NS2B-NS3 protease A125C variant at pH 8.5 | x-ray diffraction | A | — | — |
| 4M9I | A125C NS2B-NS3 protease from dengue virus at pH 5.5 | x-ray diffraction | A | — | — |
| 4M9I | A125C NS2B-NS3 protease from dengue virus at pH 5.5 | x-ray diffraction | A | — | — |
| 4M9K | NS2B-NS3 protease from dengue virus at pH 5.5 | x-ray diffraction | A | — | — |
| 4M9K | NS2B-NS3 protease from dengue virus at pH 5.5 | x-ray diffraction | A | — | — |
| 4M9M | NS2B-NS3 protease from dengue virus at pH 8.5 | x-ray diffraction | A | — | — |
| 4M9M | NS2B-NS3 protease from dengue virus at pH 8.5 | x-ray diffraction | A | — | — |
| 4M9T | NS2B-NS3 protease from dengue virus in the presence of DTNB, a covalent allosteric inhibitor | x-ray diffraction | A | — | — |
| 4M9T | NS2B-NS3 protease from dengue virus in the presence of dtnb, a covalent allosteric inhibitor | x-ray diffraction | A | — | — |
| 6KR2 | Crystal structure of Dengue virus nonstructural protein NS5 (form 1) | x-ray diffraction | A, B | ZN | — |
| 6KR2 | Crystal structure of dengue virus nonstructural protein NS5 (form 1) | x-ray diffraction | A, B | ZN | — |
| 6KR3 | Crystal structure of Dengue virus nonstructural protein NS5 (form 2) | x-ray diffraction | A, B | IOD, ZN | — |
| 6KR3 | Crystal structure of dengue virus nonstructural protein NS5 (form 2) | x-ray diffraction | A, B | IOD, ZN | — |
| 6MO0 | Structure of dengue virus protease with an allosteric inhibitor that blocks replication | x-ray diffraction | A, B | JVJ | — |
| 6MO1 | Structure of dengue virus protease with an allosteric Inhibitor that blocks replication | x-ray diffraction | A, B | I16 | — |
| 6MO1 | Structure of dengue virus protease with an allosteric inhibitor that blocks replication | x-ray diffraction | A, B | I16 | — |
| 6MO2 | Structure of dengue virus protease with an allosteric Inhibitor that blocks replication | x-ray diffraction | A, B | JVM | — |
| 6MO2 | Structure of dengue virus protease with an allosteric inhibitor that blocks replication | x-ray diffraction | A, B | JVM | — |
| 7HKH | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase… | x-ray diffraction | A | ZN, PO4, JOV | 6 (best 0.75) |
| 7HKO | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase… | x-ray diffraction | A | ZN, PO4, NUY | 6 (best 0.73) |
| 7HKQ | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase… | x-ray diffraction | A | ZN, PO4, A1BDH | 4 (best 0.77) |
| 7HKR | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase… | x-ray diffraction | A | ZN, PO4, A1BDF | 6 (best 0.75) |
| 7HKT | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase… | x-ray diffraction | A | ZN, PO4, WMS | 8 (best 0.74) |
| 7HKY | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase… | x-ray diffraction | A | ZN, PO4, UV7 | — |
| 7HL0 | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase… | x-ray diffraction | A | ZN, PO4, PYZ | 7 (best 0.76) |
| 7HL4 | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase… | x-ray diffraction | A | ZN, PO4, A1BDM | 7 (best 0.72) |
| 7HL6 | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase… | x-ray diffraction | A | ZN, PO4, A1AJS | 7 (best 0.75) |
| 7HL9 | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase… | x-ray diffraction | A | ZN, PO4, T6R | 6 (best 0.74) |
| 7XD8 | Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) | x-ray diffraction | A, D, G, J, M, P | ZN | — |
| 8T12 | Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2… | electron microscopy | B | ZN | 16 (best 0.79) |
Ligands
- ZN · Zinc ion · in 16 records
- PO4 · Phosphate ion · in 10 records
- I16 · 5-[4-(aminomethyl)phenyl]-6-[4-(furan-3-yl)phenyl]-N-[(piperidin-4-yl)methyl]pyrazin-2-amine · in 2 records
- IOD · Iodide ion · in 2 records
- JVM · 1-(4-{5-[(piperidin-4-yl)methoxy]-3-[4-(1H-pyrazol-4-yl)phenyl]pyrazin-2-yl}phenyl)methanamine · in 2 records
- A1AJS · 1-(pyridin-2-yl)piperidin-4-one · in 1 record
- A1BDF · (5R,8R)-6,7,8,9-tetrahydro-5H-5,8-epiminocyclohepta[d]pyrimidine · in 1 record
- A1BDH · N-[(1-hydroxycyclopentyl)methyl]acetamide · in 1 record
- A1BDM · 2-bromopyrimidine · in 1 record
- JOV · 3-chloro-N-(1-hydroxy-2-methylpropan-2-yl)benzamide · in 1 record
- JVJ · 1-(4-{3-[4-(furan-3-yl)phenyl]-5-[(piperidin-4-yl) methoxy]pyrazin-2-yl}phenyl)methanamine · in 1 record
- NUY · [4-(propan-2-yl)piperazin-1-yl](thiophen-2-yl)methanone · in 1 record
- PYZ · 4-iodopyrazole · in 1 record
- T6R · 1-ethyl-1H-benzimidazole · in 1 record
- UV7 · N-[(1H-pyrazol-4-yl)methyl]acetamide · in 1 record
- WMS · 5-fluoro-N-[(2-methyl-1,3-thiazol-5-yl)methyl]pyridin-3-amine · in 1 record
Elsewhere
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