Research workbench

Pseudomonas aeruginosa spm-1 metallo-beta-lactamase

Analyse Pseudomonas aeruginosa spm-1 metallo-beta-lactamase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2FHX
Type: protein
Length: 490 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spm-1
EC: 3.5.2.6
Ligands: ZN, AZI, CL
Pockets: 3 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Spm-1 (EC 3.5.2.6)	protein	245	33% helix, 27% strand	—

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B
AZI · Azide ion · ion · 3 copies · chains A, B
CL · Chloride ion · ion · chains B
EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	563	0.79	0.85	86	AZI
2	360	0.63	0.78	35	empty
3	352	0.63	0.79	38	empty

Interfaces

1 interface between chains.

A–B · 1806 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (oxidation).

Compared structures

2FHX · Pseudomonas aeruginosa SPM-1 metallo-beta-lactamase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2FHX · PDBe 2FHX

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.