Research workbench
The structure of the mammalian srp receptor
Analyse The structure of the mammalian srp receptor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FH5
- Type
- protein
- Length
- 312 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Signal recognition particle receptor alpha subunit; Signal recognition particle receptor…
- UniProt
- P08240, P47758
- Ligands
- GTP, MG
- Pockets
- 4 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Signal recognition particle receptor alpha subunit | protein | 124 | 44% helix, 23% strand | P08240 |
| B | Signal recognition particle receptor beta subunit | protein | 188 | 40% helix, 22% strand | P47758 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.53 | 0.87 | 23 | empty |
| 2 | 144 | 0.52 | 0.80 | 26 | MG, GTP |
| 3 | 80 | 0.33 | 0.75 | 19 | empty |
| 4 | 64 | 0.28 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 656 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2FH5 · The Structure of the Mammalian SRP Receptor · the same entry in another collection · chain A against A, TM-score 1.00
- P47758 · AlphaFold monomer V2.0 prediction for signal recognition particle receptor subunit beta… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P08240 · AlphaFold monomer V2.0 prediction for signal recognition particle receptor subunit alpha… · a predicted model of the same protein · chain A against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08240
- Every structure of UniProt P47758
- Elsewhere: RCSB PDB 2FH5 · PDBe 2FH5 · UniProt P08240 · UniProt P47758
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