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Crystal structure of the C2 domain of human coagulation factor V: dimeric crystal form
Analyse Crystal structure of the C2 domain of human coagulation factor V: dimeric… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1CZV
- Type
- protein
- Length
- 318 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (coagulation factor V)
- UniProt
- P12259
- Pockets
- 4 · best druggability 0.43
Structure
x-ray diffraction · 1 distinct chain · 4% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Protein (coagulation factor V) | protein | 159 | 4% helix, 50% strand | P12259 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.43 | 0.76 | 20 | empty |
| 2 | 52 | 0.43 | 0.84 | 22 | empty |
| 3 | 108 | 0.37 | 0.74 | 17 | empty |
| 4 | 97 | 0.36 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 452 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1CZV · Crystal structure of the C2 domain of human coagulation factor V: dimeric crystal form · the same entry in another collection · chain A against A, TM-score 1.00
- P12259 · AlphaFold monomer V2.0 prediction for coagulation factor V (P12259) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12259
- Elsewhere: RCSB PDB 1CZV · PDBe 1CZV · UniProt P12259
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