UniProt P12259
Coagulation factor V (P12259)
Coagulation factor V (UniProt P12259): 22 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 76 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P12259
- Protein
- Coagulation factor V
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 76 · 4 records with a druggable one
Structures
23 records of P12259 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CZS | Crystal structure of the C2 domain of human coagulation factor V: complex with phenylmercury | x-ray diffraction | A | — | — |
| 1CZS | Crystal structure of the C2 domain of human coagulation factor V: complex with phenylmercury | x-ray diffraction | A | — | — |
| 1CZT | Crystal structure of the C2 domain of human coagulation factor V | x-ray diffraction | A | — | — |
| 1CZT | Crystal structure of the C2 domain of human coagulation factor V | x-ray diffraction | A | — | — |
| 1CZV | Crystal structure of the C2 domain of human coagulation factor V: dimeric crystal form | x-ray diffraction | A, B | — | — |
| 1CZV | Crystal structure of the C2 domain of human coagulation factor V: dimeric crystal form | x-ray diffraction | A, B | — | — |
| 3P6Z | Structural basis of thrombin mediated factor V activation: essential role of the hirudin-like… | x-ray diffraction | C, I | — | — |
| 3P6Z | Structural basis of thrombin mediated factor V activation: essential role of the hirudin-like… | x-ray diffraction | C, I | — | — |
| 3P70 | Structural basis of thrombin-mediated factor V activation: essential role of the hirudin-like… | x-ray diffraction | M, N, O, P | — | — |
| 3P70 | Structural basis of thrombin-mediated factor V activation: essential role of the hirudin-like… | x-ray diffraction | M, N, O, P | — | — |
| 3S9C | Russell's viper venom serine proteinase, RVV-V in complex with the fragment (residues 1533-1546) of… | x-ray diffraction | B | — | — |
| 3S9C | RUSSELL'S viper venom serine proteinase, rvv-V in complex with the fragment (residues 1533-1546) of… | x-ray diffraction | B | — | — |
| 7KVE | Cryo-EM structure of human Factor V at 3.3 Angstrom resolution | electron microscopy | B | — | — |
| 7KVE | Cryo-EM structure of human factor V at 3.3 ångström resolution | electron microscopy | B | — | — |
| 7KVF | Cryo-EM structure of human factor V at 3.6 ångström resolution | — | — | — | |
| 7KXY | Cryo-EM structure of human Factor Va at 4.4 Angstrom resolution | electron microscopy | A, B | — | 20 (best 0.88) |
| 7KXY | Cryo-EM structure of human factor va at 4.4 ångström resolution | electron microscopy | A, B | — | — |
| 7TPP | Cryo-EM structure of human PROTHROMBIN:PROTHROMBINASE at 4.1 ångström resolution | electron microscopy | C, D | — | — |
| 7TPQ | Cryo-EM structure of human prothrombinase on a nanodisc at 5.3 ångström resolution | electron microscopy | C, D | — | — |
| 8FDG | Cryo-EM structure of coagulation factor V short | electron microscopy | A | — | 20 (best 0.85) |
| 8TN9 | Structural architecture of the acidic region of the B domain of coagulation factor V | electron microscopy | A | NAG | 20 (best 0.85) |
| 9CTH | Preliminary map of the Prothrombin-prothrombinase complex on nano discs | electron microscopy | A, E | NAG | 16 (best 0.86) |
| P12259 | AlphaFold monomer V2.0 prediction for coagulation factor V (P12259) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
Experiment against prediction
- 1CZV chain A against the predicted model P12259: TM-score 0.99, RMSD 0.53 Å
- 1CZV chain A against the predicted model P12259: TM-score 0.99, RMSD 0.53 Å
- 1CZV chain B against the predicted model P12259: TM-score 0.99, RMSD 0.53 Å
- 1CZV chain B against the predicted model P12259: TM-score 0.99, RMSD 0.53 Å
- 1CZT chain A against the predicted model P12259: TM-score 0.98, RMSD 0.78 Å
- 1CZT chain A against the predicted model P12259: TM-score 0.98, RMSD 0.78 Å
- 1CZS chain A against the predicted model P12259: TM-score 0.98, RMSD 0.85 Å
- 1CZS chain A against the predicted model P12259: TM-score 0.98, RMSD 0.85 Å
- 8TN9 chain A against the predicted model P12259: TM-score 0.95, RMSD 2.94 Å
- 3P70 chain N against the predicted model P12259: TM-score 0.94, RMSD 0.13 Å
Elsewhere
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