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Crystal structure of the ankyrin repeat domain of TRPV2

Analyse Crystal structure of the ankyrin repeat domain of TRPV2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2ETB
Type: protein
Length: 252 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily V member 2
UniProt: Q9WUD2
Pockets: 2 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transient receptor potential cation channel subfamily V member 2	protein	252	54% helix, 2% strand	Q9WUD2

Ligands and binding sites

ACY · Acetic acid · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	114	0.40	0.76	18	empty
2	50	0.29	0.75	11	empty

Compared structures

2ETB · Crystal structure of the ankyrin repeat domain of TRPV2 · the same entry in another collection · chain A against A, TM-score 1.00
Q9WUD2 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9WUD2
Elsewhere: RCSB PDB 2ETB · PDBe 2ETB · UniProt Q9WUD2

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