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Crystal structure of the cytoplasmic domain of G-protein-gated inward rectifier potassium channel KIR3.2

Analyse Crystal structure of the cytoplasmic domain of G-protein-gated inward rectifier… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2E4F
Type: protein
Length: 191 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: G protein-activated inward rectifier potassium channel 2
UniProt: P48542
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 8% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	G protein-activated inward rectifier potassium channel 2	protein	191	8% helix, 43% strand	P48542

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	170	0.52	0.79	25	empty
2	87	0.32	0.73	25	empty

Compared structures

2E4F · Crystal Structure of the Cytoplasmic Domain of G-Protein-Gated Inward Rectifier Potassium… · the same entry in another collection · chain A against A, TM-score 1.00
P48542 · AlphaFold monomer V2.0 prediction for G protein-activated inward rectifier potassium… · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48542
Elsewhere: RCSB PDB 2E4F · PDBe 2E4F · UniProt P48542

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