Research workbench
Structural basis for selection of glycosylated substrate by SCFFBS1 ubiquitin ligase
Analyse Structural basis for selection of glycosylated substrate by SCFFBS1 ubiquitin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2E31
- Type
- protein
- Length
- 379 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-box only protein 2; S-phase kinase-associated protein 1A
- UniProt
- Q80UW2, P63208
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F-box only protein 2 | protein | 246 | 21% helix, 29% strand | Q80UW2 |
| B | S-phase kinase-associated protein 1A | protein | 133 | 44% helix, 8% strand | P63208 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.37 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1661 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 2E31 · Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase · the same entry in another collection · chain A against A, TM-score 1.00
- Q80UW2 · AlphaFold monomer V2.0 prediction for F-box only protein 2 (Q80UW2) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P63208 · AlphaFold monomer V2.0 prediction for S-phase kinase-associated protein 1 (P63208) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q80UW2
- Every structure of UniProt P63208
- Elsewhere: RCSB PDB 2E31 · PDBe 2E31 · UniProt Q80UW2 · UniProt P63208
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