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Formaldehyde cross-links daunorubicin and DNA efficiently: hplc and X-ray diffraction studies

Analyse Formaldehyde cross-links daunorubicin and DNA efficiently: hplc and X-ray… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2D34
Type
DNA
Length
6 nucleotides
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
5'-D(*CP*GP*TP*(A35)P*CP*G)-3'
Ligands
DM1, MG

Structure

x-ray diffraction · 1 distinct chain.

ChainMoleculeTypeResiduesSecondary structureUniProt
A5'-D(*CP*GP*TP*(A35)P*CP*G)-3'dna6——

Ligands and binding sites

  • DM1 · Daunomycin · ligand · chains A
  • MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 1 covalent, 1 modified (covalent ligand, nucleotide modification).

Compared structures

  • 2D34 · Formaldehyde cross-links daunorubicin and DNA efficiently: hplc and X-ray diffraction… · the same entry in another collection · chain A against A, TM-score 1.00

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