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Crystal structure of murine soluble epoxide hydrolase.
Analyse Crystal structure of murine soluble epoxide hydrolase. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1CQZ
- Type
- protein
- Length
- 1,028 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Epoxide hydrolase
- EC
- 3.3.2.3
- UniProt
- P34914
- Pockets
- 10 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Epoxide hydrolase (EC 3.3.2.3) | protein | 487 | 40% helix, 15% strand | P34914 |
| B | Epoxide hydrolase (EC 3.3.2.3) | protein | 541 | 41% helix, 14% strand | P34914 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 578 | 0.84 | 0.89 | 62 | empty |
| 2 | 572 | 0.84 | 0.89 | 64 | empty |
| 3 | 464 | 0.73 | 0.82 | 49 | empty |
| 4 | 481 | 0.73 | 0.82 | 43 | empty |
| 5 | 515 | 0.68 | 0.79 | 79 | empty |
Interfaces
1 interface between chains.
- A–B · 2369 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P34914
- Elsewhere: RCSB PDB 1CQZ · PDBe 1CQZ · UniProt P34914
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