Research workbench
High resolution solution NMR structure of mixed disulfide intermediate between human thioredoxin (C35A, C62A, C69A, C73A) mutant and a 13 residue peptide comprising its target site in human ref-1 (residues 59-71 of the P50 subunit of nfkb), NMR, 31 structures
Analyse High resolution solution NMR structure of mixed disulfide intermediate between… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1CQG
- Type
- protein
- Length
- 118 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thioredoxin; Ref-1 peptide
- EC
- 4.2.99.18
- UniProt
- P10599, P27695
Structure
solution nmr · 2 distinct chains · 37% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Thioredoxin | protein | 105 | 42% helix, 28% strand | P10599 |
| B | Ref-1 peptide (EC 4.2.99.18) | protein | 13 | 0% helix, 8% strand | P27695 |
Interfaces
1 interface between chains.
- A–B · 425 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1CQG · High resolution solution NMR structure of mixed disulfide intermediate between human… · the same entry in another collection · chain A against A, TM-score 1.00
- P10599 · AlphaFold monomer V2.0 prediction for thioredoxin (P10599) · a predicted model of the same protein · chain A against A, TM-score 0.93
- P27695 · AlphaFold monomer V2.0 prediction for DNA-(apurinic or apyrimidinic site) endonuclease… · a predicted model of the same protein · chain B against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10599
- Every structure of UniProt P27695
- Elsewhere: RCSB PDB 1CQG · PDBe 1CQG · UniProt P10599 · UniProt P27695
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