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Solution structure of the zinc finger domain of transcriptional repressor ctcf protein

Analyse Solution structure of the zinc finger domain of transcriptional repressor ctcf… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2CT1
Type: protein
Length: 77 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional repressor ctcf
UniProt: P49711
Ligands: ZN
Pockets: 1 · best druggability 0.44

Structure

solution nmr · 1 distinct chain · 27% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional repressor ctcf	protein	77	27% helix, 10% strand	P49711

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.44	0.83	13	empty

Compared structures

2CT1 · Solution Structure of the zinc finger domain of Transcriptional repressor CTCF protein · the same entry in another collection · chain A against A, TM-score 1.00
P49711 · AlphaFold monomer V2.0 prediction for transcriptional repressor ctcf (P49711) · a predicted model of the same protein · chain A against A, TM-score 0.40

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49711
Elsewhere: RCSB PDB 2CT1 · PDBe 2CT1 · UniProt P49711

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