UniProt P49711
Transcriptional repressor CTCF (P49711)
Transcriptional repressor CTCF (UniProt P49711): 32 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 47 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P49711
- Protein
- Transcriptional repressor CTCF
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 47 · 7 records with a druggable one
Structures
33 records of P49711 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1X6H | Solution structures of the C2H2 type zinc finger domain of human Transcriptional repressor CTCF | solution nmr | A | — | — |
| 1X6H | Solution structures of the C2H2 type zinc finger domain of human transcriptional repressor ctcf | solution nmr | A | — | — |
| 2CT1 | Solution Structure of the zinc finger domain of Transcriptional repressor CTCF protein | solution nmr | A | — | — |
| 2CT1 | Solution structure of the zinc finger domain of transcriptional repressor ctcf protein | solution nmr | A | — | — |
| 5K5H | Homo sapiens CCCTC-binding factor (CTCF) ZnF4-7 and DNA complex structure | x-ray diffraction | A | ZN | — |
| 5K5H | Homo sapiens ccctc-binding factor (ctcf) ZNF4-7 and DNA complex structure | x-ray diffraction | A | ZN | — |
| 5K5I | Homo sapiens CCCTC-binding factor (CTCF) ZnF5-8 and DNA complex structure in space group P65 | x-ray diffraction | A | ZN, SO4 | — |
| 5K5I | Homo sapiens ccctc-binding factor (ctcf) ZNF5-8 and DNA complex structure in space group P65 | x-ray diffraction | A | ZN, SO4 | — |
| 5K5J | Homo sapiens CCCTC-binding factor (CTCF) ZnF5-8 and DNA complex structure in space group P41212 | x-ray diffraction | A | ZN, SO4 | 3 (best 0.54) |
| 5K5J | Homo sapiens ccctc-binding factor (ctcf) ZNF5-8 and DNA complex structure in space group P41212 | x-ray diffraction | A | ZN, SO4 | — |
| 5K5L | Homo sapiens CCCTC-binding factor (CTCF) ZnF6-8 and H19 sequence DNA complex structure | x-ray diffraction | E, F, G | ZN | 6 (best 0.70) |
| 5K5L | Homo sapiens ccctc-binding factor (ctcf) ZNF6-8 and H19 sequence DNA complex structure | x-ray diffraction | E, F, G | ZN | — |
| 5KKQ | Homo sapiens CCCTC-binding factor (CTCF) ZnF3-7 and DNA complex structure | x-ray diffraction | A, D | ZN | 6 (best 0.62) |
| 5KKQ | Homo sapiens ccctc-binding factor (ctcf) ZNF3-7 and DNA complex structure | x-ray diffraction | A, D | ZN | — |
| 5T00 | Human ctcf ZNF3-7 and methylated DNA complex | x-ray diffraction | A, D | ZN | — |
| 5T0U | Ctcf ZNF2-7 and DNA complex structure | x-ray diffraction | A, D | ZN | — |
| 5UND | Crystal Structure of CTCF(ZnF 4-10) With 28-mer DNA | x-ray diffraction | A, B | ZN | — |
| 5UND | Crystal structure of CTCF(ZNF 4-10) with 28-mer DNA | x-ray diffraction | A, B | ZN | — |
| 5YEF | Crystal structure of CTCF ZFs2-8-Hs5-1aE | x-ray diffraction | A, B, G, J | ZN | — |
| 5YEF | Crystal structure of ctcf ZFS2-8-HS5-1AE | x-ray diffraction | A, B, G, J | ZN | — |
| 5YEG | Crystal structure of CTCF ZFs4-8-Hs5-1a complex | x-ray diffraction | A, B | ZN | — |
| 5YEG | Crystal structure of ctcf ZFS4-8-HS5-1A complex | x-ray diffraction | A, B | ZN | — |
| 5YEH | Crystal structure of CTCF ZFs4-8-eCBS | x-ray diffraction | A, B | ZN | — |
| 5YEH | Crystal structure of ctcf ZFS4-8-ecbs | x-ray diffraction | A, B | ZN | — |
| 5YEL | Crystal structure of ctcf ZFS6-11-GB7CSE | x-ray diffraction | A, B | ZN | — |
| 6QNX | Structure of the SA2/SCC1/CTCF complex | x-ray diffraction | C | — | — |
| 6QNX | Structure of the SA2/SCC1/CTCF complex | x-ray diffraction | C | — | — |
| 7W1M | Cryo-EM structure of human cohesin-CTCF-DNA complex | electron microscopy | H | ZN | — |
| 8SSQ | ZnFs 3-11 of CCCTC-binding factor (CTCF) Complexed with 35mer DNA 35-4 | x-ray diffraction | A, D | ZN, NA | 15 (best 0.73) |
| 8SSS | ZnFs 1-7 of CCCTC-binding factor (CTCF) Complexed with 23mer | x-ray diffraction | A, D | ZN, NA | 6 (best 0.70) |
| 8SST | ZnFs 1-7 of CCCTC-binding factor (CTCF) K365T Mutant Complexed with 23mer | x-ray diffraction | A, D | ZN | 7 (best 0.69) |
| 8SSU | ZnFs 3-11 of CCCTC-binding factor (CTCF) Complexed with 19mer DNA | x-ray diffraction | A | ZN | 4 (best 0.55) |
| P49711 | AlphaFold monomer V2.0 prediction for transcriptional repressor ctcf (P49711) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5K5L chain E against the predicted model P49711: TM-score 0.95, RMSD 0.61 Å
- 5K5L chain E against the predicted model P49711: TM-score 0.95, RMSD 0.61 Å
- 5K5L chain F against the predicted model P49711: TM-score 0.88, RMSD 1.40 Å
- 5K5L chain F against the predicted model P49711: TM-score 0.88, RMSD 1.40 Å
- 5K5H chain A against the predicted model P49711: TM-score 0.88, RMSD 1.60 Å
- 5K5H chain A against the predicted model P49711: TM-score 0.88, RMSD 1.60 Å
- 5YEG chain A against the predicted model P49711: TM-score 0.85, RMSD 2.15 Å
- 5YEG chain A against the predicted model P49711: TM-score 0.85, RMSD 2.15 Å
- 5YEH chain A against the predicted model P49711: TM-score 0.83, RMSD 2.30 Å
- 5YEH chain A against the predicted model P49711: TM-score 0.83, RMSD 2.30 Å
Elsewhere
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