Research workbench
Despentapeptide insulin in acetic acid (pH 2)
Analyse Despentapeptide insulin in acetic acid (pH 2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2CEU
- Type
- protein
- Length
- 90 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin
- UniProt
- P01308
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Insulin | protein | 21 | 57% helix, 5% strand | P01308 |
| B, D | Insulin | protein | 24 | 50% helix, 4% strand | P01308 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 75 | 0.55 | 0.86 | 17 | empty |
Interfaces
6 interfaces between chains.
- A–B · 638 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 636 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 421 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 112 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 109 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 2CEU · Despentapeptide insulin in acetic acid (pH 2) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 2CEU · PDBe 2CEU · UniProt P01308
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