Mouse succinic semialdehyde reductase, AKR7A5

Structure

x-ray diffraction · 2 distinct chains · 49% helix, 15% strand (DSSP).

Ligands and binding sites

• NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 10 copies · chains A, B, C, D, E, F, G, H, I, J
• PO4 · Phosphate ion · ion · 2 copies · chains A, G, J
• GOL · Glycerol · additive · 25 copies · chains A, B, F, C, D, E, G, H, J, I
• TLA · L(+)-tartaric acid · additive · 10 copies · chains A, B, C, D, E, F, G, H, I, J
• MES · 2-(N-morpholino)-ethanesulfonic acid · additive · 5 copies · chains B, F, C, D, E, I, G, J

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Interfaces

10 interfaces between chains.

• B–F · 1014 Ų buried · 23 hydrogen bonds · protein-protein
• G–J · 1012 Ų buried · 20 hydrogen bonds · protein-protein
• D–E · 1011 Ų buried · 22 hydrogen bonds · protein-protein
• E–F · 871 Ų buried · 10 hydrogen bonds · protein-protein
• G–H · 868 Ų buried · 9 hydrogen bonds · protein-protein

Compared structures

• 2C91 · mouse succinic semialdehyde reductase, AKR7A5 · the same entry in another collection · chain J against J, TM-score 1.00
• Q8CG76 · AlphaFold monomer V2.0 prediction for aflatoxin B1 aldehyde reductase member 2 (Q8CG76) · a predicted model of the same protein · chain F against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8CG76
• Elsewhere: RCSB PDB 2C91 · PDBe 2C91 · UniProt Q8CG76