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Structure and activity of a flavonoid 3-O glucosyltransferase reveals the basis for plant natural product modification
Analyse Structure and activity of a flavonoid 3-O glucosyltransferase reveals the basis… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2C1X
- Type
- protein
- Length
- 434 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Udp-glucose flavonoid 3-O glycosyltransferase
- EC
- 2.4.1.91
- UniProt
- O22304
- Ligands
- UDP
- Pockets
- 3 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 49% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Udp-glucose flavonoid 3-O glycosyltransferase (EC 2.4.1.91) | protein | 434 | 49% helix, 14% strand | O22304 |
Ligands and binding sites
- UDP · Uridine-5'-diphosphate · ligand · chains A
- B3P · 2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 692 | 0.77 | 0.82 | 81 | UDP, B3P |
| 2 | 69 | 0.56 | 0.87 | 15 | empty |
| 3 | 91 | 0.39 | 0.77 | 15 | empty |
Compared structures
- 2C1X · Structure and activity of a flavonoid 3-O glucosyltransferase reveals the basis for plant… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O22304
- Elsewhere: RCSB PDB 2C1X · PDBe 2C1X · UniProt O22304
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