Research workbench
NUP50:IMPORTIN-alpha complex
Analyse NUP50:IMPORTIN-alpha complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2C1M
- Type
- protein
- Length
- 470 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin-ALPHA2 subunit; Nucleoporin 50 kda
- UniProt
- P52293, Q9JIH2
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin-ALPHA2 subunit | protein | 424 | 74% helix, 0% strand | P52293 |
| B | Nucleoporin 50 kda | protein | 46 | 9% helix, 2% strand | Q9JIH2 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.47 | 0.83 | 13 | empty |
| 2 | 55 | 0.41 | 0.82 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 2363 Ų buried · 52 hydrogen bonds · protein-protein
Compared structures
- 2C1M · Nup50:importin-alpha complex · the same entry in another collection · chain A against A, TM-score 1.00
- P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain A against A, TM-score 0.93
- Q9JIH2 · AlphaFold monomer V2.0 prediction for nuclear pore complex protein NUP50 (Q9JIH2) · a predicted model of the same protein · chain B against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt Q9JIH2
- Elsewhere: RCSB PDB 2C1M · PDBe 2C1M · UniProt P52293 · UniProt Q9JIH2
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