Research workbench
Crystal structure of E. COLI GTP cyclohydrolase II in complex with GTP analogue, gmpcpp, and zinc
Analyse Crystal structure of E. COLI GTP cyclohydrolase II in complex with GTP… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2BZ0
- Type
- protein
- Length
- 341 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP cyclohydrolase II
- EC
- 3.5.4.25
- UniProt
- P0A7I7
- Ligands
- G2P, ZN, MG
- Pockets
- 4 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GTP cyclohydrolase II (EC 3.5.4.25) | protein | 168 | 29% helix, 30% strand | P0A7I7 |
| B | GTP cyclohydrolase II (EC 3.5.4.25) | protein | 173 | 31% helix, 29% strand | P0A7I7 |
Ligands and binding sites
- G2P · Phosphomethylphosphonic acid guanylate ester · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 349 | 0.64 | 0.80 | 38 | MG, G2P |
| 2 | 284 | 0.61 | 0.79 | 34 | ZN, G2P |
| 3 | 350 | 0.58 | 0.76 | 30 | empty |
| 4 | 167 | 0.54 | 0.79 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 1683 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2BZ0 · Crystal Structure of E. coli GTP cyclohydrolase II in complex with GTP analogue, GMPcPP… · the same entry in another collection · chain A against A, TM-score 1.00
- P0A7I7 · AlphaFold monomer V2.0 prediction for GTP cyclohydrolase-2 (P0A7I7) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A7I7
- Elsewhere: RCSB PDB 2BZ0 · PDBe 2BZ0 · UniProt P0A7I7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.