UniProt P0A7I7
GTP cyclohydrolase II (P0A7I7)
GTP cyclohydrolase II (UniProt P0A7I7), EC 3.5.4.25: 4 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0A7I7
- Protein
- GTP cyclohydrolase II
- EC
- 3.5.4.25
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 8 · 3 records with a druggable one
Structures
5 records of P0A7I7 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2BZ0 | Crystal Structure of E. coli GTP cyclohydrolase II in complex with GTP analogue, GMPcPP, and Zinc | x-ray diffraction | A, B | ZN, MG, G2P | 4 (best 0.64) |
| 2BZ0 | Crystal structure of E. COLI GTP cyclohydrolase II in complex with GTP analogue, gmpcpp, and zinc | x-ray diffraction | A, B | — | — |
| 2BZ1 | Crystal structure of apo E. COLI GTP cyclohydrolase II | x-ray diffraction | A | ZN, SO4, TAU | 2 (best 0.58) |
| 2BZ1 | Crystal structure of apo E. COLI GTP cyclohydrolase II | x-ray diffraction | A | — | — |
| P0A7I7 | AlphaFold monomer V2.0 prediction for GTP cyclohydrolase-2 (P0A7I7) | predicted | A | — | 2 (best 0.77) |
Ligands
Experiment against prediction
- 2BZ0 chain B against the predicted model P0A7I7: TM-score 0.99, RMSD 0.55 Å
- 2BZ0 chain B against the predicted model P0A7I7: TM-score 0.99, RMSD 0.55 Å
- 2BZ0 chain A against the predicted model P0A7I7: TM-score 0.98, RMSD 0.67 Å
- 2BZ0 chain A against the predicted model P0A7I7: TM-score 0.98, RMSD 0.67 Å
- 2BZ1 chain A against the predicted model P0A7I7: TM-score 0.98, RMSD 0.77 Å
- 2BZ1 chain A against the predicted model P0A7I7: TM-score 0.98, RMSD 0.77 Å
Elsewhere
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