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Structure of the camp responsive exchange factor EPAC2 in its auto-inhibited state

Analyse Structure of the camp responsive exchange factor EPAC2 in its auto-inhibited… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2BYV
Type: protein
Length: 922 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rap guanine nucleotide exchange factor 4
UniProt: Q9EQZ6
Pockets: 15 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
E	Rap guanine nucleotide exchange factor 4	protein	922	48% helix, 16% strand	Q9EQZ6

Pockets

15 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	601	0.68	0.78	69	empty
2	532	0.65	0.77	56	empty
3	59	0.63	0.93	23	empty
4	248	0.50	0.74	30	empty
5	96	0.48	0.80	22	empty

Compared structures

2BYV · Structure of the cAMP responsive exchange factor Epac2 in its auto- inhibited state · the same entry in another collection · chain E against E, TM-score 1.00
Q9EQZ6 · AlphaFold monomer V2.0 prediction for rap guanine nucleotide exchange factor 4 (Q9EQZ6) · a predicted model of the same protein · chain E against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9EQZ6
Elsewhere: RCSB PDB 2BYV · PDBe 2BYV · UniProt Q9EQZ6

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