UniProt Q9EQZ6
Rap guanine nucleotide exchange factor 4 (Q9EQZ6)
Rap guanine nucleotide exchange factor 4 (UniProt Q9EQZ6): 14 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 98 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9EQZ6
- Protein
- Rap guanine nucleotide exchange factor 4
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 98 · 8 records with a druggable one
Structures
15 records of Q9EQZ6 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2BYV | Structure of the cAMP responsive exchange factor Epac2 in its auto- inhibited state | x-ray diffraction | E | — | — |
| 2BYV | Structure of the camp responsive exchange factor EPAC2 in its auto-inhibited state | x-ray diffraction | E | — | 15 (best 0.68) |
| 4F7Z | Conformational dynamics of exchange protein directly activated by cAMP | x-ray diffraction | A | — | 14 (best 0.72) |
| 4F7Z | Conformational dynamics of exchange protein directly activated by camp | x-ray diffraction | A | — | — |
| 4MGI | Selective activation of Epac1 and Epac2 | x-ray diffraction | E | CMP | 11 (best 0.78) |
| 4MGI | Selective activation of EPAC1 and EPAC2 | x-ray diffraction | E | — | — |
| 4MGK | Selective activation of Epac1 and Epac2 | x-ray diffraction | E | CMP | 12 (best 0.78) |
| 4MGK | Selective activation of EPAC1 and EPAC2 | x-ray diffraction | E | — | — |
| 4MGY | Selective activation of Epac1 and Epac2 | x-ray diffraction | E | H07 | 10 (best 0.77) |
| 4MGY | Selective activation of EPAC1 and EPAC2 | x-ray diffraction | E | — | — |
| 4MGZ | Selective activation of Epac1 and Epac2 | x-ray diffraction | E | HR6 | 10 (best 0.77) |
| 4MGZ | Selective activation of EPAC1 and EPAC2 | x-ray diffraction | E | — | — |
| 4MH0 | Selective activation of Epac1 and Epac2 | x-ray diffraction | E | HR4 | 10 (best 0.78) |
| 4MH0 | Selective activation of EPAC1 and EPAC2 | x-ray diffraction | E | — | — |
| Q9EQZ6 | AlphaFold monomer V2.0 prediction for rap guanine nucleotide exchange factor 4 (Q9EQZ6) | predicted | A | — | 16 (best 0.75) |
Ligands
- CMP · Adenosine-3',5'-cyclic-monophosphate · in 2 records
- H07 · (2S,4aR,6R,7R,7aR)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-methoxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-ol 2-oxide · in 1 record
- HR4 · (2S,4aR,6R,7R,7aS)-6-{6-amino-8-[(4-fluorobenzyl)sulfanyl]-9H-purin-9-yl}-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide · in 1 record
- HR6 · (2S,4aR,6R,7R,7aS)-6-[6-amino-8-(benzylsulfanyl)-9H-purin-9-yl]-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide · in 1 record
Experiment against prediction
- 4F7Z chain A against the predicted model Q9EQZ6: TM-score 0.99, RMSD 1.06 Å
- 4F7Z chain A against the predicted model Q9EQZ6: TM-score 0.99, RMSD 1.06 Å
- 2BYV chain E against the predicted model Q9EQZ6: TM-score 0.98, RMSD 1.65 Å
- 2BYV chain E against the predicted model Q9EQZ6: TM-score 0.98, RMSD 1.65 Å
- 4MGZ chain E against the predicted model Q9EQZ6: TM-score 0.78, RMSD 1.28 Å
- 4MGZ chain E against the predicted model Q9EQZ6: TM-score 0.78, RMSD 1.28 Å
- 4MH0 chain E against the predicted model Q9EQZ6: TM-score 0.78, RMSD 1.26 Å
- 4MH0 chain E against the predicted model Q9EQZ6: TM-score 0.78, RMSD 1.26 Å
- 4MGI chain E against the predicted model Q9EQZ6: TM-score 0.78, RMSD 1.27 Å
- 4MGI chain E against the predicted model Q9EQZ6: TM-score 0.78, RMSD 1.27 Å
Elsewhere
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