MolNFT v1 · #91262 · protein
Conformational dynamics of exchange protein directly activated by camp
4F7Z · Rap guanine nucleotide exchange factor 4: “Conformational dynamics of exchange protein directly activated by camp”. X-ray diffraction, 14 pockets (best druggability 0.72). MolNFT v1 #91262 on GenesisL1: 3D structure, binding sites…
- PDB
- 4F7Z
- Type
- protein
- Length
- 946 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rap guanine nucleotide exchange factor 4
- UniProt
- Q9EQZ6
- Pockets
- 14 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rap guanine nucleotide exchange factor 4 | protein | 946 | 48% helix, 17% strand | Q9EQZ6 |
Ligands and binding sites
- GOL · Glycerol · additive · 7 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 435 | 0.72 | 0.82 | 44 | empty |
| 2 | 53 | 0.69 | 0.97 | 19 | GOL |
| 3 | 537 | 0.66 | 0.77 | 59 | GOL |
| 4 | 348 | 0.55 | 0.74 | 45 | empty |
| 5 | 100 | 0.47 | 0.79 | 15 | empty |
Compared structures
- 4F7Z · Conformational dynamics of exchange protein directly activated by cAMP · the same entry in another collection · chain A against A, TM-score 1.00
- Q9EQZ6 · AlphaFold monomer V2.0 prediction for rap guanine nucleotide exchange factor 4 (Q9EQZ6) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9EQZ6
- Elsewhere: RCSB PDB 4F7Z · PDBe 4F7Z · UniProt Q9EQZ6
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