Ligand · HR6

HR6 · (2S,4aR,6R,7R,7aS)-6-[6-amino-8-(benzylsulfanyl)-9H-purin-9-yl]-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide

HR6, (2S,4aR,6R,7R,7aS)-6-[6-amino-8-(benzylsulfanyl)-9H-purin-9-yl]-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide (C17 H18 N5 O5 P S2, 467.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component: HR6
Formula: C17 H18 N5 O5 P S2
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

HR6 in 2 structures; the first of them:

4MGZ · Selective activation of Epac1 and Epac2 · HR6 E1001 · binds PHE367, VAL386, ILE388, VAL394, CYS395, LEU397, ASP401, ASP402 and 15 more
4MGZ · Selective activation of EPAC1 and EPAC2 · HR6 E1001 · binds PHE367, VAL386, ILE388, VAL394, CYS395, LEU397, ASP401, ASP402 and 15 more

Residues it binds most

VAL 4, ALA 2, GLY 4, ILE 4, LEU 2, LYS 2, ARG 2, ASP 2, PHE 2, SER 2 (residue and the binding sites it lines).

Found with

SO4 · Sulfate ion

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