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Crystal structure of mycobacterium tuberculosis lipoprotein lppx (RV2945C)

Analyse Crystal structure of mycobacterium tuberculosis lipoprotein lppx (RV2945C) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2BYO
Type: protein
Length: 183 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipoprotein lppx
UniProt: P65306
Ligands: LNL, HXA, OAA, MLT, ZN
Pockets: 1 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lipoprotein lppx	protein	183	16% helix, 51% strand	P65306

Ligands and binding sites

LNL · Alpha-linolenic acid · ligand · 2 copies · chains A
HXA · Docosa-4,7,10,13,16,19-hexaenoic acid · ligand · chains A
OAA · Oxaloacetate ion · ligand · chains A
MLT · D-malate · ligand · chains A
ZN · Zinc ion · metal · 6 copies · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1117	0.79	0.81	62	HXA, LNL

Compared structures

2BYO · Crystal structure of Mycobacterium tuberculosis lipoprotein LppX (Rv2945c) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P65306
Elsewhere: RCSB PDB 2BYO · PDBe 2BYO · UniProt P65306

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