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Phosphorylated MAP kinase P38-gamma

Analyse Phosphorylated MAP kinase P38-gamma in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1CM8
Type: protein
Length: 658 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphorylated MAP kinase P38-gamma
UniProt: P53778
Ligands: ANP, MG
Pockets: 8 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Phosphorylated MAP kinase P38-gamma	protein	329	39% helix, 14% strand	P53778

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	333	0.62	0.78	43	MG, ANP
2	191	0.61	0.82	25	MG, ANP
3	153	0.44	0.75	22	MG
4	148	0.44	0.75	29	empty
5	127	0.42	0.75	28	empty

Interfaces

1 interface between chains.

A–B · 312 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (phosphorylation).

Compared structures

1CM8 · Phosphorylated MAP kinase P38-gamma · the same entry in another collection · chain A against A, TM-score 1.00
P53778 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 12 (P53778) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53778
Elsewhere: RCSB PDB 1CM8 · PDBe 1CM8 · UniProt P53778

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