UniProt P53778
Mitogen-activated protein kinase 12 (P53778)
Mitogen-activated protein kinase 12 (UniProt P53778): 6 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P53778
- Protein
- Mitogen-activated protein kinase 12
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 4 · 1 record with a druggable one
Structures
7 records of P53778 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CM8 | Phosphorylated MAP kinase P38-gamma | x-ray diffraction | A, B | — | — |
| 1CM8 | Phosphorylated MAP kinase P38-gamma | x-ray diffraction | A, B | — | — |
| 4QUM | Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide | x-ray diffraction | B | — | — |
| 4QUM | Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide | x-ray diffraction | B | — | — |
| 6UNA | Crystal structure of inactive P38GAMMA | x-ray diffraction | A, B | SO4 | — |
| 7CGA | Crystal structure of human unphosphorylated P38GAMMA | x-ray diffraction | A, B, C, D | — | — |
| P53778 | AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 12 (P53778) | predicted | A | — | 4 (best 0.71) |
Ligands
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 6UNA chain B against the predicted model P53778: TM-score 0.96, RMSD 1.44 Å
- 6UNA chain A against the predicted model P53778: TM-score 0.95, RMSD 1.45 Å
- 7CGA chain A against the predicted model P53778: TM-score 0.93, RMSD 2.01 Å
- 1CM8 chain A against the predicted model P53778: TM-score 0.93, RMSD 2.02 Å
- 1CM8 chain A against the predicted model P53778: TM-score 0.93, RMSD 2.02 Å
- 4QUM chain B against the predicted model P53778: TM-score 0.53, RMSD 1.68 Å
- 4QUM chain B against the predicted model P53778: TM-score 0.53, RMSD 1.68 Å
Elsewhere
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