Research workbench
Structure of N-terminal FAD binding motif of mouse mical
Analyse Structure of N-terminal FAD binding motif of mouse mical in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2BRA
- Type
- protein
- Length
- 951 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NEDD9 interacting protein with calponin homology and lim domains
- UniProt
- Q8VDP3
- Ligands
- FAD, CL
- Pockets
- 10 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NEDD9 interacting protein with calponin homology and lim domains | protein | 473 | 40% helix, 21% strand | Q8VDP3 |
| B | NEDD9 interacting protein with calponin homology and lim domains | protein | 478 | 40% helix, 20% strand | Q8VDP3 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
- CL · Chloride ion · ion · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 524 | 0.76 | 0.83 | 70 | FAD |
| 2 | 432 | 0.75 | 0.84 | 61 | FAD |
| 3 | 479 | 0.74 | 0.83 | 71 | empty |
| 4 | 369 | 0.55 | 0.74 | 56 | empty |
| 5 | 90 | 0.52 | 0.84 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 908 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8VDP3
- Elsewhere: RCSB PDB 2BRA · PDBe 2BRA · UniProt Q8VDP3
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