Research workbench
X-ray structure of the general secretion pathway complex of the N-terminal domain of epse and the cytosolic domain of epsl of vibrio cholerae
Analyse X-ray structure of the general secretion pathway complex of the N-terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2BH1
- Type
- protein
- Length
- 612 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- General secretion pathway protein L; General secretion pathway protein E,
- UniProt
- P45782, P37093
- Ligands
- CA
- Pockets
- 7 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | General secretion pathway protein L | protein | 238 | 30% helix, 37% strand | P45782 |
| X, Y | General secretion pathway protein E, | protein | 68 | 43% helix, 22% strand | P37093 |
Ligands and binding sites
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 696 | 0.68 | 0.76 | 62 | empty |
| 2 | 80 | 0.54 | 0.86 | 24 | empty |
| 3 | 82 | 0.51 | 0.84 | 25 | empty |
| 4 | 145 | 0.48 | 0.78 | 21 | empty |
| 5 | 52 | 0.36 | 0.80 | 12 | empty |
Interfaces
3 interfaces between chains.
- A–X · 945 Ų buried · 6 hydrogen bonds · protein-protein
- B–Y · 909 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 375 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2BH1 · X-ray structure of the general secretion pathway complex of the N- terminal domain of… · the same entry in another collection · chain A against A, TM-score 1.00
- P45782 · AlphaFold monomer V2.0 prediction for type II secretion system protein L (P45782) · a predicted model of the same protein · chain A against A, TM-score 1.00
- P37093 · AlphaFold monomer V2.0 prediction for type II secretion system ATPase E (P37093) · a predicted model of the same protein · chain X against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P45782
- Every structure of UniProt P37093
- Elsewhere: RCSB PDB 2BH1 · PDBe 2BH1 · UniProt P45782 · UniProt P37093
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.