Research workbench
Electron crystallographic structure of lens aquaporin-0 (AQP0) (lens mip) at 1.9A resolution, in a closed pore state
Analyse Electron crystallographic structure of lens aquaporin-0 (AQP0) (lens mip) at… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2B6O
- Type
- protein
- Length
- 235 residues
- Chains
- 1
- Method
- electron crystallography
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lens fiber major intrinsic protein
- UniProt
- Q6J8I9
- Ligands
- MC3
- Pockets
- 2 · best druggability 0.45
Structure
electron crystallography · 1 distinct chain · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lens fiber major intrinsic protein | protein | 235 | 68% helix, 0% strand | Q6J8I9 |
Ligands and binding sites
- MC3 · 1,2-dimyristoyl-rac-glycero-3-phosphocholine · ligand · 9 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.45 | 0.76 | 23 | empty |
| 2 | 51 | 0.26 | 0.73 | 13 | empty |
Compared structures
- 2B6O · Electron crystallographic structure of lens Aquaporin-0 (AQP0) (lens MIP) at 1.9A… · the same entry in another collection · chain A against A, TM-score 1.00
- Q6J8I9 · AlphaFold monomer V2.0 prediction for lens fiber major intrinsic protein (Q6J8I9) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6J8I9
- Elsewhere: RCSB PDB 2B6O · PDBe 2B6O · UniProt Q6J8I9
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