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Crystal structure of human tyrosine phosphatase shp-1

Analyse Crystal structure of human tyrosine phosphatase shp-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2B3O
Type: protein
Length: 504 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase, non-receptor type 6
EC: 3.1.3.48
UniProt: P29350
Pockets: 5 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein phosphatase, non-receptor type 6 (EC 3.1.3.48)	protein	504	27% helix, 23% strand	P29350

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1028	0.76	0.79	66	empty
2	93	0.65	0.91	36	empty
3	109	0.42	0.77	22	empty
4	77	0.42	0.80	13	empty
5	50	0.33	0.78	14	empty

Compared structures

2B3O · Crystal structure of human tyrosine phosphatase SHP-1 · the same entry in another collection · chain A against A, TM-score 1.00
P29350 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 6… · a predicted model of the same protein · chain A against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29350
Elsewhere: RCSB PDB 2B3O · PDBe 2B3O · UniProt P29350

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