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Tandem chromodomains of human CHD1
Analyse Tandem chromodomains of human CHD1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2B2Y
- Type
- protein
- Length
- 430 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromodomain-helicase-DNA-binding protein 1
- UniProt
- O14646
- Pockets
- 7 · best druggability 0.85
Structure
x-ray diffraction · 3 distinct chains · 41% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromodomain-helicase-DNA-binding protein 1 | protein | 175 | 42% helix, 25% strand | O14646 |
| B | Chromodomain-helicase-DNA-binding protein 1 | protein | 169 | 45% helix, 21% strand | O14646 |
| C | Chromodomain-helicase-DNA-binding protein 1 | protein | 86 | 31% helix, 28% strand | O14646 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 936 | 0.85 | 0.86 | 113 | empty |
| 2 | 99 | 0.46 | 0.80 | 20 | empty |
| 3 | 100 | 0.45 | 0.79 | 23 | empty |
| 4 | 137 | 0.45 | 0.76 | 18 | empty |
| 5 | 50 | 0.44 | 0.83 | 9 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1375 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 310 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 303 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14646
- Elsewhere: RCSB PDB 2B2Y · PDBe 2B2Y · UniProt O14646
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