Research workbench
Structure of USP14 bound to ubquitin aldehyde
Analyse Structure of USP14 bound to ubquitin aldehyde in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2AYO
- Type
- protein
- Length
- 431 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin carboxyl-terminal hydrolase 14; Ubiquitin
- EC
- 3.1.2.15
- UniProt
- P54578, P62988
- Pockets
- 9 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 23% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15) | protein | 355 | 24% helix, 23% strand | P54578 |
| B | Ubiquitin | protein | 76 | 20% helix, 32% strand | P62988 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.69 | 0.96 | 23 | empty |
| 2 | 66 | 0.67 | 0.94 | 20 | empty |
| 3 | 216 | 0.52 | 0.77 | 30 | empty |
| 4 | 178 | 0.50 | 0.78 | 32 | empty |
| 5 | 84 | 0.48 | 0.82 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1651 Ų buried · 26 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (nonstandard).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54578
- Every structure of UniProt P62988
- Elsewhere: RCSB PDB 2AYO · PDBe 2AYO · UniProt P54578 · UniProt P62988
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