UniProt P54578
Ubiquitin carboxyl-terminal hydrolase 14 (P54578)
Ubiquitin carboxyl-terminal hydrolase 14 (UniProt P54578), EC 3.4.19.12: 21 experimental structures on GenesisL1, 5 ligands bound, 21 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P54578
- Protein
- Ubiquitin carboxyl-terminal hydrolase 14
- EC
- 3.4.19.12
- Experimental structures
- 21
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 21 · 4 records with a druggable one
Structures
21 records of P54578 in the MolNFT archive: 21 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2AYN | Structure of USP14, a proteasome-associated deubiquitinating enzyme | x-ray diffraction | A, B, C | — | — |
| 2AYN | Structure of USP14, a proteasome-associated deubiquitinating enzyme | x-ray diffraction | A, B, C | — | — |
| 2AYO | Structure of USP14 bound to ubquitin aldehyde | x-ray diffraction | A | — | — |
| 2AYO | Structure of USP14 bound to ubquitin aldehyde | x-ray diffraction | A | — | — |
| 5GJQ | Structure of the human 26S proteasome bound to USP14-ubal | electron microscopy | x | — | — |
| 6IIK | USP14 catalytic domain with IU1 | x-ray diffraction | A, B | IU1 | 9 (best 0.52) |
| 6IIK | USP14 catalytic domain with IU1 | x-ray diffraction | A, B | IU1 | — |
| 6IIL | USP14 catalytic domain bind to IU1-47 | x-ray diffraction | A, B | A8F | 7 (best 0.55) |
| 6IIL | USP14 catalytic domain bind to IU1-47 | x-ray diffraction | A, B | A8F | — |
| 6IIM | USP14 catalytic domain with IU1-206 | x-ray diffraction | A, B | A8L | — |
| 6IIN | USP14 catalytic domain with IU1-248 | x-ray diffraction | A, B | A8O | — |
| 6IIN | USP14 catalytic domain with IU1-248 | x-ray diffraction | A, B | A8O | — |
| 6LVS | USP14 catalytic domain mutant C114S | x-ray diffraction | A, B, C, D, E, F | NA | — |
| 6LVS | USP14 catalytic domain mutant C114S | x-ray diffraction | A, B, C, D, E, F | NA | — |
| 7W37 | Structure of USP14-bound human 26S proteasome in state EA1_UBL | electron microscopy | x | — | — |
| 7W38 | Structure of USP14-bound human 26S proteasome in state EA2.0_UBL | electron microscopy | x | — | — |
| 7W39 | Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | electron microscopy | x | — | — |
| 7W3B | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED5_USP14 | electron microscopy | x | — | 4 (best 0.84) |
| 7W3H | Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.1_USP14 | electron microscopy | x | — | 1 (best 0.79) |
| 7W3I | Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | electron microscopy | x | — | — |
| P54578 | AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 14 (P54578) | — | — | — |
Ligands
- A8F · 1-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(piperidin-1-yl)ethan-1-one · in 2 records
- A8O · 4-{3-[(4-hydroxypiperidin-1-yl)acetyl]-2,5-dimethyl-1H-pyrrol-1-yl}benzonitrile · in 2 records
- IU1 · 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one · in 2 records
- NA · Sodium ion · in 2 records
- A8L · 1-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(4-hydroxypiperidin-1-yl)ethan-1-one · in 1 record
Elsewhere
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