Research workbench
Structure of USP14, a proteasome-associated deubiquitinating enzyme
Analyse Structure of USP14, a proteasome-associated deubiquitinating enzyme in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2AYN
- Type
- protein
- Length
- 1,011 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin carboxyl-terminal hydrolase 14
- EC
- 3.1.2.15
- UniProt
- P54578
- Pockets
- 14 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15) | protein | 337 | 29% helix, 26% strand | P54578 |
Pockets
14 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1175 | 0.76 | 0.78 | 84 | empty |
| 2 | 433 | 0.60 | 0.75 | 45 | empty |
| 3 | 118 | 0.50 | 0.80 | 16 | empty |
| 4 | 131 | 0.49 | 0.78 | 13 | empty |
| 5 | 132 | 0.46 | 0.77 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–C · 594 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 501 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 230 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2AYN · Structure of USP14, a proteasome-associated deubiquitinating enzyme · the same entry in another collection · chain A against A, TM-score 1.00
- P54578 · AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 14 (P54578) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54578
- Elsewhere: RCSB PDB 2AYN · PDBe 2AYN · UniProt P54578
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.